MaP555 is a small-molecule fluorogenic probe with excellent cell permeability. It is converted from 6-carboxytetramethylrhodamine (6-TAMRA) and has similar spectroscopic properties of 6-TAMRA. MaP555 has an acyl sulfamide structure which favors the spirolactam form, thus has excellent cell permeability. When the probe binds to its cellular targets, MaP555 mainly exists in the fluorescent zwitterion form. The good spectroscopic properties, high cell permeability and outstanding fluorogenicity of MaP555 make it very useful for wash-free, multicolour, live-cell nanoscopy. MaP555 NHS is an amine-reactive reagent. It can be used to label proteins, peptides, and modified oligonucleotides containing amine groups. Excitation maximum = 553 nm; emission maximum = 580 nm.
| Product Name | MaP555 NHS |
| Synonyms | |
| CAS Number | N/A |
| Related CAS | |
| Molecular Formula | C31H31N5O8S |
| Molecular Weight | 633.68 |
| Purity (HPLC) | >= 95% |
| Physical Appearance | Orange solid |
| Optical Properties | Abs/Em Maxima: 553/580 nm |
| Solubility | DMSO |
| Shipping Conditions | Shipped on gel packs |
| Storage Conditions | Store at -20°C and protected from light |
| Shelf Life | 12 months after the date of delivery |
| Regulatory Statement | For Research Use Only |
References
Wang, L., Tran, M., D’Este, E., Roberti, J., Koch, B., Xue, L., & Johnsson, K. (2020). A general strategy to develop cell permeable and fluorogenic probes for multicolour nanoscopy. Nature Chemistry, 12(2), 165–172. https://doi.org/10.1038/s41557-019-0371-1
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