Compound AN2 reduces mHTT levels through autophagic degradation by interacting with both the autophagosome protein microtubule-associated protein 1A/1B light chain 3 (LC3)1 and mutant huntingtin protein (mHTT). AN2 reduces the levels of mHTT in an allele-selective manner in cultured Huntington disease (HD) mouse neurons.
| Product Name | AN2 |
| Synonyms | 5,7-dihydroxy-4-phenylcoumarin |
| CAS Number | 7758-73-8 |
| Related CAS | |
| Molecular Formula | C15H10O4 |
| Molecular Weight | 254.241 |
| SMILES | OC1=CC(O)=C2C(OC(=O)C=C2C2=CC=CC=C2)=C1 |
| Purity (HPLC) | >= 95% |
| Physical Appearance | White solid |
| Solubility | DMSO, DMF |
| Shipping Conditions | Room Temperature |
| Storage Conditions | Refrigerated |
| Shelf Life | 12 months after the date of delivery |
| Regulatory Statement | For Research Use Only |
References
Li, Z., Wang, C., Wang, Z., Zhu, C., Li, J., Sha, T., Ma, L., Gao, C., Yang, Y., Sun, Y., Wang, J., Sun, X., Lu, C., Difiglia, M., Mei, Y., Ding, C., Luo, S., Dang, Y., Ding, Y., … Lu, B. (2019). Allele-selective lowering of mutant HTT protein by HTT–LC3 linker compounds. Nature, 575(7781), 203–209. https://doi.org/10.1038/s41586-019-1722-1
Documents
Datasheet COA MSDS
Citations
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