Compound I-13 induces degradation of Ikaros (IKZF1) through recruitment of CRBN( EC50: 0.006 uM).
| Product Name | compound I-13 |
| Synonyms | |
| CAS Number | 2631059-94-2 |
| Related CAS | |
| Molecular Formula | C12H11N3O3 |
| Molecular Weight | 245.238 |
| SMILES | CC1=CC2=C(C=C1)C(=NO2)N1CCC(=O)NC1=O |
| Purity (HPLC) | >= 95% |
| Physical Appearance | White solid |
| Solubility | DMSO, DMF |
| Shipping Conditions | Room Temperature |
| Storage Conditions | Refrigerated |
| Shelf Life | 12 months after the date of delivery |
| Regulatory Statement | For Research Use Only |
References
Axford, J., Beckwith, R. E. J., BONAZZI, S., Buschmann, N., CERNIJENKO, A., DEWHURST, J., FAZAL, A., HESSE, M. J., HOLDER, L., HORNAK, V., Imase, H., Jain, R., Jin, X., Kerrigan, J. R., Lachal, J., Ma, F., Malik, H. A., MANNING, J. R., Mckay, D., MOREAU, R. J., NIMSGERN, P., O'Brien, G., Vulpetti, A., Yamada, K.,Zhao, J. Glue degraders and methods of use thereof. WO 2021/053555, 2021.
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Citations
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