(R)-CR8 acts as a molecular glue degrader that depletes cyclin K.
| Product Name | CR8 |
| Synonyms | |
| CAS Number | 294646-77-8 |
| Related CAS | |
| Molecular Formula | C25H30N6O |
| Molecular Weight | 430.556 |
| SMILES | CC[C@H](CO)CC1=NC(NCC2=CC=C(C=C2)C2=CC=CC=N2)=C2N=CN(C(C)C)C2=N1 |
| Purity (HPLC) | >= 95% |
| Physical Appearance | White solid |
| Solubility | DMSO, DMF |
| Shipping Conditions | Room Temperature |
| Storage Conditions | Refrigerated |
| Shelf Life | 12 months after the date of delivery |
| Regulatory Statement | For Research Use Only |
References
S?abicki, M., Kozicka, Z., Petzold, G., Li, Y.-D., Manojkumar, M., Bunker, R. D., Donovan, K. A., Sievers, Q. L., Koeppel, J., Suchyta, D., Sperling, A. S., Fink, E. C., Gasser, J. A., Wang, L. R., Corsello, S. M., Sellar, R. S., Jan, M., Gillingham, D., Scholl, C., Frohling, S., Golub, T. R., Fischer, E. S., Thoma, N. H.,Ebert, B. L., The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K. Nature 2020, 585, 293-297.Kozicka, Z.,Thomä, N. H., Haven't got a glue: Protein surface variation for the design of molecular glue degraders. Cell Chemical Biology 2021, 28, 1032-1047.S?abicki, M., Yoon, H., Koeppel, J., Nitsch, L., Roy Burman, S. S., Di Genua, C., Donovan, K. A., Sperling, A. S., Hunkeler, M., Tsai, J. M., Sharma, R., Guirguis, A., Zou, C., Chudasama, P., Gasser, J. A., Miller, P. G., Scholl, C., Frohling, S., Nowak, R. P., Fischer, E. S.,Ebert, B. L., Small-molecule-induced polymerization triggers degradation of BCL6. Nature 2020, 588, 164-168.
Documents
Datasheet COA MSDS
Citations
If you know of a paper that uses this product from Tenova Pharma, please let us know.