TMX-4116 is a casein kinase 1a (CK1a) degrader. TMX-4116 shows the degradation preference for CK1a with DC50s less than 200 nM in MOLT4, Jurkat, and MM.1S cells. TMX-4116 can be used for the research of multiple myeloma.
| Product Name | TMX-4116 |
| Synonyms | |
| CAS Number | 2766385-56-0 |
| Related CAS | |
| Molecular Formula | C17H19N5O4S |
| Molecular Weight | 389.43 |
| SMILES | COC1=C(SC=C1C1=CN(N=N1)C1CCC(=O)NC1=O)C(=O)N1CCCC1 |
| Purity (HPLC) | >= 95% |
| Physical Appearance | White solid |
| Solubility | DMSO, DMF |
| Shipping Conditions | Room Temperature |
| Storage Conditions | Refrigerated |
| Shelf Life | 12 months after the date of delivery |
| Regulatory Statement | For Research Use Only |
References
Teng, M., Lu, W., Donovan, K. A., Sun, J., Krupnick, N. M., Nowak, R. P., Li, Y.-D., Sperling, A. S., Zhang, T., Ebert, B. L., Fischer, E. S.,Gray, N. S., Development of PDE6D and CK1a Degraders through Chemical Derivatization of FPFT-2216. Journal of Medicinal Chemistry 2022, 65, 747-756.
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Citations
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