{"title":"Azide-mPEG-VA-OH ADC Linkers","description":"","products":[{"product_id":"azide-lysm-peg4-val-ala-oh","title":"Azide-Lys(m-PEG4)-Val-Ala-OH","description":"\u003cp\u003e\u003cspan\u003eSOLU-KNEX® cleavable linker features a Val-Ala dipeptide. In this product, a Azide-Lys(m-PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility.  The azide functional group is widely utilized in bioconjugation via click chemistry to enable efficient and selective attachment of biomolecules.   \n  \u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e Derived from established ADC linker architectures, SOLU-KNEX® ADC linkers integrate solubilizing moieties—such as PEG, amine-containing groups, or polysarcosine (PSAR), to enhance aqueous solubility.  Solubility and physicochemical properties can be finely tuned through selection and combination of these groups, making the linkers highly adaptable for diverse ADC and related applications.  SOLU-KNEX® is a registered trademark of Tenova Pharmaceuticals, Inc.  For research use only.\u003c\/span\u003e\u003c\/p\u003e\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003eProduct Name\u003c\/td\u003e\n\u003ctd style=\"width: 65%;\"\u003eAzide-Lys(m-PEG4)-Val-Ala-OH\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003eSynonyms\u003c\/td\u003e\n\u003ctd style=\"width: 65%;\"\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003eCAS Number\u003c\/td\u003e\n\u003ctd style=\"width: 65%;\"\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003eRelated CAS\u003c\/td\u003e\n\u003ctd style=\"width: 65%;\"\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003eMolecular Formula\u003c\/td\u003e\n\u003ctd style=\"width: 65%;\"\u003eC24H44N6O9\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003eMolecular Weight\u003c\/td\u003e\n\u003ctd style=\"width: 65%;\"\u003e560.649\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003ePurity (HPLC)\u003c\/td\u003e\n\u003ctd style=\"width: 65%;\"\u003e\u0026gt;= 95%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003eSolubility\u003c\/td\u003e\n\u003ctd style=\"width: 65%;\"\u003eDMSO, DMF\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003eShipping Conditions\u003c\/td\u003e\n\u003ctd style=\"width: 65%;\"\u003eShipped on gel packs\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003eStorage Conditions\u003c\/td\u003e\n\u003ctd style=\"width: 65%;\"\u003eStore at -20°C and protected from light\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003eShelf Life\u003c\/td\u003e\n\u003ctd style=\"width: 65%;\"\u003e12 months after the  date of delivery \u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003eRegulatory Statement\u003c\/td\u003e\n\u003ctd style=\"width: 65%;\"\u003eFor Research Use Only\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003ch5\u003eReferences\u003c\/h5\u003e\u003cp\u003e\u003cspan\u003e(1) Lee, H. M., Abdul-Hadi, K., Appleman, V. A., Cardin, D., Dong, L., England, D., Ganno, M. L., Gershman, R., Gigstad, K., Gulavita, N., Hu, Z., Huang, J., Huang, S. C., Lok, D., Ma, L., Malley, J., Mizutani, M., Molchanova, N., Piatkov, K. I., … Abu-Yousif, A. O. (2025). Identification of a Novel Linker Enabling the Bioconjugation of a Cyclic Dinucleotide for the STING Antibody-Drug Conjugate TAK-500. Bioconjugate Chemistry, 36(11), 2423–2435. https:\/\/doi.org\/10.1021\/acs.bioconjchem.5c00434\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ch5\u003eDocuments \u003cbr\u003e\n\u003c\/h5\u003e\n\u003cp\u003e\u003cspan style=\"color: #3171b8;\"\u003eDatasheet          MSDS\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ch5\u003eCitations\u003c\/h5\u003e\n\u003cp\u003e\u003cspan\u003eIf you know of a paper that uses this product from Tenova Pharma, \u003cspan style=\"color: #3171b8;\"\u003e\u003ca style=\"color: #3171b8;\" href=\"https:\/\/tenovapharma.com\/pages\/suggest-a-citation\"\u003eplease let us know\u003c\/a\u003e\u003c\/span\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch5\u003e\u003c\/h5\u003e","brand":"Tenova Pharmaceuticals","offers":[{"title":"10mg","offer_id":44508146335830,"sku":"T72076-10mg","price":490.0,"currency_code":"USD","in_stock":false},{"title":"25mg","offer_id":44508146368598,"sku":"T72076-25mg","price":790.0,"currency_code":"USD","in_stock":false},{"title":"50mg","offer_id":44508146401366,"sku":"T72076-50mg","price":1190.0,"currency_code":"USD","in_stock":false},{"title":"100mg","offer_id":44508146434134,"sku":"T72076-100mg","price":1790.0,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0282\/8953\/1990\/files\/T72076.gif?v=1776275964"},{"product_id":"azide-dapm-peg4-val-ala-oh","title":"Azide-Dap(m-PEG4)-Val-Ala-OH","description":"\u003cp\u003e\u003cspan\u003eSOLU-KNEX® cleavable linker features a Val-Ala dipeptide. In this product, a Azide-Dap(m-PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility.  The azide functional group is widely utilized in bioconjugation via click chemistry to enable efficient and selective attachment of biomolecules.   \n  \u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e Derived from established ADC linker architectures, SOLU-KNEX® ADC linkers integrate solubilizing moieties—such as PEG, amine-containing groups, or polysarcosine (PSAR), to enhance aqueous solubility.  Solubility and physicochemical properties can be finely tuned through selection and combination of these groups, making the linkers highly adaptable for diverse ADC and related applications.  SOLU-KNEX® is a registered trademark of Tenova Pharmaceuticals, Inc.  For research use only.\u003c\/span\u003e\u003c\/p\u003e\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003eProduct Name\u003c\/td\u003e\n\u003ctd style=\"width: 65%;\"\u003eAzide-Dap(m-PEG4)-Val-Ala-OH\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003eSynonyms\u003c\/td\u003e\n\u003ctd style=\"width: 65%;\"\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003eCAS Number\u003c\/td\u003e\n\u003ctd style=\"width: 65%;\"\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003eRelated CAS\u003c\/td\u003e\n\u003ctd style=\"width: 65%;\"\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003eMolecular Formula\u003c\/td\u003e\n\u003ctd style=\"width: 65%;\"\u003eC21H38N6O9\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003eMolecular Weight\u003c\/td\u003e\n\u003ctd style=\"width: 65%;\"\u003e518.568\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003ePurity (HPLC)\u003c\/td\u003e\n\u003ctd style=\"width: 65%;\"\u003e\u0026gt;= 95%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003eSolubility\u003c\/td\u003e\n\u003ctd style=\"width: 65%;\"\u003eDMSO, DMF\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003eShipping Conditions\u003c\/td\u003e\n\u003ctd style=\"width: 65%;\"\u003eShipped on gel packs\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003eStorage Conditions\u003c\/td\u003e\n\u003ctd style=\"width: 65%;\"\u003eStore at -20°C and protected from light\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003eShelf Life\u003c\/td\u003e\n\u003ctd style=\"width: 65%;\"\u003e12 months after the  date of delivery \u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003eRegulatory Statement\u003c\/td\u003e\n\u003ctd style=\"width: 65%;\"\u003eFor Research Use Only\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003ch5\u003eReferences\u003c\/h5\u003e\u003cp\u003e\u003cspan\u003e(1) Lee, H. M., Abdul-Hadi, K., Appleman, V. A., Cardin, D., Dong, L., England, D., Ganno, M. L., Gershman, R., Gigstad, K., Gulavita, N., Hu, Z., Huang, J., Huang, S. C., Lok, D., Ma, L., Malley, J., Mizutani, M., Molchanova, N., Piatkov, K. I., … Abu-Yousif, A. O. (2025). Identification of a Novel Linker Enabling the Bioconjugation of a Cyclic Dinucleotide for the STING Antibody-Drug Conjugate TAK-500. Bioconjugate Chemistry, 36(11), 2423–2435. https:\/\/doi.org\/10.1021\/acs.bioconjchem.5c00437\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ch5\u003eDocuments \u003cbr\u003e\n\u003c\/h5\u003e\n\u003cp\u003e\u003cspan style=\"color: #3171b8;\"\u003eDatasheet          MSDS\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ch5\u003eCitations\u003c\/h5\u003e\n\u003cp\u003e\u003cspan\u003eIf you know of a paper that uses this product from Tenova Pharma, \u003cspan style=\"color: #3171b8;\"\u003e\u003ca style=\"color: #3171b8;\" href=\"https:\/\/tenovapharma.com\/pages\/suggest-a-citation\"\u003eplease let us know\u003c\/a\u003e\u003c\/span\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch5\u003e\u003c\/h5\u003e","brand":"Tenova Pharmaceuticals","offers":[{"title":"10mg","offer_id":44508146827350,"sku":"T72079-10mg","price":490.0,"currency_code":"USD","in_stock":false},{"title":"25mg","offer_id":44508146860118,"sku":"T72079-25mg","price":790.0,"currency_code":"USD","in_stock":false},{"title":"50mg","offer_id":44508146892886,"sku":"T72079-50mg","price":1190.0,"currency_code":"USD","in_stock":false},{"title":"100mg","offer_id":44508146925654,"sku":"T72079-100mg","price":1790.0,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0282\/8953\/1990\/files\/T72079.gif?v=1776275964"}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0282\/8953\/1990\/collections\/adc_azide_2_b7790423-355c-4f34-a890-14731d392236.png?v=1776278438","url":"https:\/\/tenovapharma.com\/en-gb\/collections\/azide-mpeg-va-oh-adc-linkers.oembed","provider":"Tenova Pharma","version":"1.0","type":"link"}