{"product_id":"halo-dbf","title":"Halo-DBF","description":"\u003cp\u003e\u003cspan\u003eHalo-DBF is a HaloTag-reactive dibromofluorescein photosensitizer designed for spatially controlled biomolecule labeling in living cells. Upon covalent binding to a HaloTag fusion protein, Halo-DBF localizes singlet-oxygen generation to a selected protein, organelle, or subcellular compartment. Visible-light activation oxidizes nearby guanosine residues in RNA, enabling capture by propargylamine and subsequent click-chemistry conjugation to biotin or fluorescent probes for enrichment, imaging, RT-qPCR, or RNA-seq analysis. This reagent supports proximity-based profiling of localized RNAs at nuclear, cytoplasmic, nucleolar, mitochondrial, and other defined cellular sites while preserving native cellular organization. Halo-DBF is well suited for RNA localization studies, transcriptome mapping, organelle-associated RNA analysis, and development of HaloTag-enabled chemical biology workflows.\u003c\/span\u003e\u003c\/p\u003e\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003eProduct Name\u003c\/td\u003e\n\u003ctd style=\"width: 65%;\"\u003eHalo-DBF\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003eSynonyms\u003c\/td\u003e\n\u003ctd style=\"width: 65%;\"\u003eHalo-Dibromofluorescein\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003eCAS Number\u003c\/td\u003e\n\u003ctd style=\"width: 65%;\"\u003eN\/A\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003eRelated CAS\u003c\/td\u003e\n\u003ctd style=\"width: 65%;\"\u003eN\/A\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003eMolecular Formula\u003c\/td\u003e\n\u003ctd style=\"width: 65%;\"\u003eC35H34Br2ClNO10\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003eMolecular Weight\u003c\/td\u003e\n\u003ctd style=\"width: 65%;\"\u003e823.91\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003ePurity (HPLC)\u003c\/td\u003e\n\u003ctd style=\"width: 65%;\"\u003e\u0026gt;= 95%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003eSolubility\u003c\/td\u003e\n\u003ctd style=\"width: 65%;\"\u003eDMSO, DMF\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003eShipping Conditions\u003c\/td\u003e\n\u003ctd style=\"width: 65%;\"\u003eShipped on gel packs\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003eStorage Conditions\u003c\/td\u003e\n\u003ctd style=\"width: 65%;\"\u003eStore at -20°C and protected from light\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003eShelf Life\u003c\/td\u003e\n\u003ctd style=\"width: 65%;\"\u003e12 months after the  date of delivery \u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003eRegulatory Statement\u003c\/td\u003e\n\u003ctd style=\"width: 65%;\"\u003eFor Research Use Only\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003ch5\u003eReferences\u003c\/h5\u003e\u003cp\u003e\u003cspan\u003e(1) Engel, K. L., Lo, H. Y. G., Goering, R., Li, Y., Spitale, R. C., \u0026amp; Matthew Taliaferro, J. (2022). Analysis of subcellular transcriptomes by RNA proximity labeling with Halo-seq. Nucleic Acids Research, 50(4), E24. https:\/\/doi.org\/10.1093\/nar\/gkab1185\n\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e \n(2) Li, Y., Aggarwal, M. B., Nguyen, K., Ke, K., \u0026amp; Spitale, R. C. (2017). Assaying RNA Localization in Situ with Spatially Restricted Nucleobase Oxidation. ACS Chemical Biology, 12(11), 2709–2714. https:\/\/doi.org\/10.1021\/acschembio.7b00519\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ch5\u003eDocuments \u003cbr\u003e\n\u003c\/h5\u003e\n\u003cp\u003e\u003cspan style=\"color: #3171b8;\"\u003eDatasheet          MSDS\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ch5\u003eCitations\u003c\/h5\u003e\n\u003cp\u003e\u003cspan\u003eIf you know of a paper that uses this product from Tenova Pharma, \u003cspan style=\"color: #3171b8;\"\u003e\u003ca style=\"color: #3171b8;\" href=\"https:\/\/tenovapharma.com\/pages\/suggest-a-citation\"\u003eplease let us know\u003c\/a\u003e\u003c\/span\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch5\u003e\u003c\/h5\u003e","brand":"Tenova Pharmaceuticals","offers":[{"title":"100nmol","offer_id":50569503735894,"sku":"T01406-100nmol","price":375.55,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0282\/8953\/1990\/files\/vial99.png?v=1710708227","url":"https:\/\/tenovapharma.com\/en-gb\/products\/halo-dbf","provider":"Tenova Pharma","version":"1.0","type":"link"}