{"product_id":"mal-propionyl-peg4-val-cit-pabm-peg4-exatecan","title":"Mal-Propionyl-PEG4-Val-Cit-PAB(m-PEG4)-Exatecan","description":"\u003cp\u003e\u003cspan\u003eSOLU-KNEX® cleavable linker features a Val-Cit dipeptide.  The conventional maleimidocaproyl (MC) unit is replaced by Mal-Propionyl-PEG4 moiety to enhance aqueous solubility.  The Mal-Propionyl group may also improve retro-Michael addition stability during antibody conjugation. m-PEG4 is attached to the commonly used self-immolative para-aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I inhibitor derived from camptothecin, which induces DNA damage by stabilizing the topoisomerase I–DNA complex, resulting in cell-cycle arrest and apoptosis. \n  \u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e Derived from established ADC linker architectures, SOLU-KNEX® ADC linkers integrate solubilizing moieties—such as PEG, amine-containing groups, or polysarcosine (PSAR), to enhance aqueous solubility.  Solubility and physicochemical properties can be finely tuned through selection and combination of these groups, making the linkers highly adaptable for diverse ADC and related applications.  SOLU-KNEX® is a registered trademark of Tenova Pharmaceuticals, Inc.  For research use only.\u003c\/span\u003e\u003c\/p\u003e\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003eProduct Name\u003c\/td\u003e\n\u003ctd style=\"width: 65%;\"\u003eMal-Propionyl-PEG4-Val-Cit-PAB(m-PEG4)-Exatecan\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003eSynonyms\u003c\/td\u003e\n\u003ctd style=\"width: 65%;\"\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003eCAS Number\u003c\/td\u003e\n\u003ctd style=\"width: 65%;\"\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003eRelated CAS\u003c\/td\u003e\n\u003ctd style=\"width: 65%;\"\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003eMolecular Formula\u003c\/td\u003e\n\u003ctd style=\"width: 65%;\"\u003eC71H94FN11O22\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003eMolecular Weight\u003c\/td\u003e\n\u003ctd style=\"width: 65%;\"\u003e1472.586\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003ePurity (HPLC)\u003c\/td\u003e\n\u003ctd style=\"width: 65%;\"\u003e\u0026gt;= 95%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003eSolubility\u003c\/td\u003e\n\u003ctd style=\"width: 65%;\"\u003eDMSO, DMF\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003eShipping Conditions\u003c\/td\u003e\n\u003ctd style=\"width: 65%;\"\u003eShipped on gel packs\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003eStorage Conditions\u003c\/td\u003e\n\u003ctd style=\"width: 65%;\"\u003eStore at -20°C and protected from light\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003eShelf Life\u003c\/td\u003e\n\u003ctd style=\"width: 65%;\"\u003e12 months after the  date of delivery \u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003eRegulatory Statement\u003c\/td\u003e\n\u003ctd style=\"width: 65%;\"\u003eFor Research Use Only\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003ch5\u003eReferences\u003c\/h5\u003e\u003cp\u003e\u003cspan\u003e(1) Yamazoe, S., Poudel, Y., Sega, E., Mukhopadhyay, A., Ramakrishnan, R., Ukairo, O., Liu, S., Akter, R., Sadanala, K., Que, K., Cheng, Q., Kotapati, S., Deshpande, M., Cox, M., Chourey, S., Gupta, A., Kempson, J., Pabbisetty, K., Kaspady, M., … Chekler, E. P. (2025). Discovery and Characterization of a First-in-Class LIV1-TLR7\/8 Immunomodulatory Conjugate with Robust Myeloid Activation and Antitumor Activity. Journal of Medicinal Chemistry. https:\/\/doi.org\/10.1021\/acs.jmedchem.5c00339\n \u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003e (2) Wang, L., Hobson, A. D., Salomon, P. L., Fitzgibbons, J., Xu, J., McCarthy, S., Wu, K., Jia, Y., Hernandez, A., Li, X., Xu, Z., Wang, Z., Yu, Y., Li, J., \u0026amp; Tao, L. (2023). Linker substitution influences succinimide ring hydrolysis equilibrium impacting the stability of attachment to antibody-drug conjugates. RSC Medicinal Chemistry, 15(2), 612–622. https:\/\/doi.org\/10.1039\/d3md00569k\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ch5\u003eDocuments \u003cbr\u003e\n\u003c\/h5\u003e\n\u003cp\u003e\u003cspan style=\"color: #3171b8;\"\u003eDatasheet          MSDS\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ch5\u003eCitations\u003c\/h5\u003e\n\u003cp\u003e\u003cspan\u003eIf you know of a paper that uses this product from Tenova Pharma, \u003cspan style=\"color: #3171b8;\"\u003e\u003ca style=\"color: #3171b8;\" href=\"https:\/\/tenovapharma.com\/pages\/suggest-a-citation\"\u003eplease let us know\u003c\/a\u003e\u003c\/span\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch5\u003e\u003c\/h5\u003e","brand":"Tenova Pharmaceuticals","offers":[{"title":"1mg","offer_id":44498335891542,"sku":"T71142-1mg","price":668.42,"currency_code":"GBP","in_stock":false},{"title":"5mg","offer_id":44502899621974,"sku":"T71142-5mg","price":2020.28,"currency_code":"GBP","in_stock":false},{"title":"10mg","offer_id":44502899654742,"sku":"T71142-10mg","price":3071.72,"currency_code":"GBP","in_stock":false},{"title":"25mg","offer_id":44502899687510,"sku":"T71142-25mg","price":4648.89,"currency_code":"GBP","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0282\/8953\/1990\/files\/T71142.gif?v=1775954007","url":"https:\/\/tenovapharma.com\/en-gb\/products\/mal-propionyl-peg4-val-cit-pabm-peg4-exatecan","provider":"Tenova Pharma","version":"1.0","type":"link"}