NIR-ASM (NIR NQO1 live cell probe)



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NIR-ASM is a NAD(P)H quinone oxidoreductase 1 (NQO1)-activatable NIR fluorescent probe. It is a conjugate between dicyanoisophorone (ASM) fluorophore and the NQO1 substrate quinone propionic acid (QPA). NIR-ASM remained non-fluorescent until activation by NQO1, whose expression is largely limited to malignant tissues. It has a large Stokes shift (186 nm) and a prominent near-infrared emission (646 nm) in response to NQO1. NIR-ASM is capable of monitoring NQO1 activity in vitro and in vivo with high specificity and selectivity. NIR-ASM has been demonstrated to differentiate cancer cells from normal cells based on NQO1 activity using fluorescence microscopy and flow cytometry. Excitation maximum = 465 nm; emission maximum = 646 nm. Reference: Punganuru, S. R., Madala, H. R., Arutla, V., Zhang, R., & Srivenugopal, K. S. (2019). Characterization of a highly specific NQO1-activated near-infrared fluorescent probe and its application for in vivo tumor imaging. Scientific Reports, 9(1).

Product Name NIR-ASM
CAS Number 2646628-35-3
Related CAS
Molecular Formula C33H35N3O3
Molecular Weight 521.661
Purity (HPLC) >= 95%
Shipping Conditions Shipped on gel packs
Storage Conditions Store at -20°C and protected from light
Regulatory Statement For Research Use Only