{"product_id":"pc-6","title":"PC-6","description":"\u003cp\u003e\u003cspan\u003ePC-6 is a specially designed fluorescent probe for detecting SARM1 activity, built by conjugating a styryl donor group to a pyridine acceptor to form a donor–\u003cspan class=\"texhtml mvar\"\u003eπ\u003c\/span\u003e–acceptor system. It functions through SARM1’s base-exchange reaction, where PC-6 is converted into a positively charged product (PAD6) upon incorporation into NAD, leading to strong intramolecular charge transfer and a large fluorescence shift (from ~430 nm to ~520 nm). Among a series of related probes (PC1–9), PC-6 shows the largest fluorescence increase, high sensitivity (detecting as little as 48 ng\/mL enzyme), and strong selectivity for SARM1 over other NADases, making it a powerful tool for monitoring SARM1 activation in biochemical assays. \u003c\/span\u003e\u003c\/p\u003e\n\u003ctable width=\"100%\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003eProduct Name\u003c\/td\u003e\n\u003ctd style=\"width: 65%;\"\u003ePC-6\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003eSynonyms\u003c\/td\u003e\n\u003ctd style=\"width: 65%;\"\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003eCAS Number\u003c\/td\u003e\n\u003ctd style=\"width: 65%;\"\u003eN\/A\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003eRelated CAS\u003c\/td\u003e\n\u003ctd style=\"width: 65%;\"\u003eN\/A\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003eMolecular Formula\u003c\/td\u003e\n\u003ctd style=\"width: 65%;\"\u003eC15H15NO\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003eMolecular Weight\u003c\/td\u003e\n\u003ctd style=\"width: 65%;\"\u003e225.291\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003ePurity (HPLC)\u003c\/td\u003e\n\u003ctd style=\"width: 65%;\"\u003e\u0026gt;= 95%\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003eSolubility\u003c\/td\u003e\n\u003ctd style=\"width: 65%;\"\u003eDMSO, DMF\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003eShipping Conditions\u003c\/td\u003e\n\u003ctd style=\"width: 65%;\"\u003eShipped on gel packs\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003eStorage Conditions\u003c\/td\u003e\n\u003ctd style=\"width: 65%;\"\u003eStore at -20°C and protected from light\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003eShelf Life\u003c\/td\u003e\n\u003ctd style=\"width: 65%;\"\u003e12 months after the date of delivery\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"width: 30%;\"\u003eRegulatory Statement\u003c\/td\u003e\n\u003ctd style=\"width: 65%;\"\u003eFor Research Use Only\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e\u003cbr\u003e\u003c\/p\u003e\n\u003ch5\u003eReferences\u003c\/h5\u003e\n\u003cp\u003e\u003cspan\u003eLi, W. H., Huang, K., Cai, Y., Wang, Q. W., Zhu, W. J., Hou, Y. N., Wang, S., Cao, S., Zhao, Z. Y., Xie, X. J., Du, Y., Lee, C. S., Lee, H. C., Zhang, H., \u0026amp; Zhao, Y. J. (2021). Permeant fluorescent probes visualize the activation of sarm1 and uncover an antineurodegenerative drug candidate. eLife, 10. https:\/\/doi.org\/10.7554\/eLife.67381\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ch5\u003eDocuments \u003cbr\u003e\n\u003c\/h5\u003e\n\u003cp\u003e\u003cspan style=\"color: #3171b8;\"\u003eDatasheet          MSDS\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ch5\u003eCitations\u003c\/h5\u003e\n\u003cp\u003e\u003cspan\u003eIf you know of a paper that uses this product from Tenova Pharma, \u003cspan style=\"color: #3171b8;\"\u003e\u003ca style=\"color: #3171b8;\" href=\"https:\/\/tenovapharma.com\/pages\/suggest-a-citation\"\u003eplease let us know\u003c\/a\u003e\u003c\/span\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch5\u003e\u003cbr\u003e\u003c\/h5\u003e","brand":"Tenova Pharmaceuticals","offers":[{"title":"100nmol","offer_id":44270969258070,"sku":"T01403-100nmol","price":490.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0282\/8953\/1990\/files\/vial99.png?v=1710708227","url":"https:\/\/tenovapharma.com\/products\/pc-6","provider":"Tenova Pharma","version":"1.0","type":"link"}