BC-Alexa Fluor 488
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CLIP-tag is a modified version of the SNAP-tag. It is also a self-labeling protein derived from human O6-alkylguanine-DNA-alkyltransferase. Unlike the SNAP-tag, which reacts with benzylguanine (BG)or chloropyrimidine (CP) derivatives, the CLIP-tag is engineered to specifically interact with benzylcytosine (BC)derivatives. This modification allows for distinct labeling applications, enabling researchers to use both SNAP-tag and CLIP-tag in the same experiment, providing flexibility in protein labeling and tracking. BC-Alexa Fluor 488 is a CLIP-tag substrate containg Alexa Fluor 488 dye and it forms a covalent bond with the CLIP-tag protein, ensuring stable labeling for long-term tracking. Alexa Fluor 488 (494Ex/517Em) is a popular green fluorescent dye known for its brightness, stability, and versatility in various biological and biochemical applications.
| Product Name | BC-Alexa Fluor 488 |
| Synonyms | CLIP-Alexa Fluor 488 |
| CAS Number | |
| Related CAS | |
| Molecular Formula | C33H24N6O11S2 |
| Molecular Weight | 744.71 |
| Purity (HPLC) | >= 95% |
| Solubility | DMSO, DMF |
| Shipping Conditions | Shipped on gel packs |
| Storage Conditions | Store at -20°C and protected from light |
| Shelf Life | 12 months after the date of delivery |
| Regulatory Statement | For Research Use Only |
References
Wilhelm, J., Kuhn, S., Tarnawski, M., Gotthard, G., Tunnermann, J., Tanzer, T., Karpenko, J., Mertes, N., Xue, L., Uhrig, U., Reinstein, J., Hiblot, J., & Johnsson, K. (2021). Kinetic and Structural Characterization of the Self-Labeling Protein Tags HaloTag7, SNAP-tag, and CLIP-tag. Biochemistry, 60(33), 2560–2575. https://doi.org/10.1021/acs.biochem.1c00264
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