Custom Synthesis Services
With years of expertise in synthetic chemistry, our team excels in the design and synthesis of organic molecules for pharmaceuticals, biotech, and academic research.
Here are some examples of our work:
- Hit-to-lead follow-up libraries
- Lead optimization SAR study
- ADC linker-payloads
- PROTACs and Molecular Glues
- Reference compounds
- Stable-Isotope labelled compounds
- Fluorescent probes
- Bioactive compounds for assay development
- Bioconjugation reagents
Antibody-Drug Conjugates (ADC) Project
Our Client: A Pharmaceutical Company
Project: Linker-payload synthesis for antibody drug conjugation
Results:
- Conducted synthesis using variety of linkers and payloads such as: DBCO, MC, PEG, Val-Cit-PAB, Gly-Gly-Phe-Gly, MMAF, MMAE, α-Amanitin, Exatecan, etc.
- Successfully obtained target linker-payloads through HPLC purification and lyophilization
Small Molecule Medicinal Chemistry Project
Our Client: A Pharmaceutical Company
Project: Kinase Inhibitors - Hit to Lead and Lead Optimization
Results:
- Developed hit compound modification strategies
- Conducted extensive Structure Activity Relationship (SAR) studies
- Synthesized over 200 compounds
- Coordinated compound profiling through other vendors
- Discovered potent, selective, and orally bioavailable lead compounds
- Supported client on patent filings
Academic Research Project
Our Client: An Academic Research Group
Project: Protein Tyrosine Phosphatases Inhibitors - Hit to Lead and Lead Optimization
Results:
- Worked on multiple projects
- Developed synthetic methods with diverse chemistry
- Synthesized over 300 compounds
- Scaled up the lead compound at 100 gram scale
- Supported client on publishing the results on leading scientific journals
Custom Synthesis Project
Our Client: A Biotech Startup
Project: Synthesis of Chemiluminescence Compounds
Results:
- Other CROs failed on the synthesis
- Re-designed the synthesis route
- Fine-tuned the reaction conditions
- Completed the 8-step synthesis successfully
- Produced several hundred mg of the final products