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Tenova Pharmaceuticals  |  SKU: T55037-5mg

CR8

$290.00
Size

(R)-CR8 acts as a molecular glue degrader that depletes cyclin K.

Product Name CR8
Synonyms
CAS Number 294646-77-8
Related CAS
Molecular Formula C25H30N6O
Molecular Weight 430.556
SMILES CC[C@H](CO)CC1=NC(NCC2=CC=C(C=C2)C2=CC=CC=N2)=C2N=CN(C(C)C)C2=N1
Purity (HPLC) >= 95%
Physical Appearance White solid
Solubility DMSO, DMF
Shipping Conditions Room Temperature
Storage Conditions Refrigerated
Shelf Life 12 months after the date of delivery
Regulatory Statement For Research Use Only


References

S?abicki, M., Kozicka, Z., Petzold, G., Li, Y.-D., Manojkumar, M., Bunker, R. D., Donovan, K. A., Sievers, Q. L., Koeppel, J., Suchyta, D., Sperling, A. S., Fink, E. C., Gasser, J. A., Wang, L. R., Corsello, S. M., Sellar, R. S., Jan, M., Gillingham, D., Scholl, C., Frohling, S., Golub, T. R., Fischer, E. S., Thoma, N. H.,Ebert, B. L., The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K. Nature 2020, 585, 293-297.Kozicka, Z.,Thomä, N. H., Haven't got a glue: Protein surface variation for the design of molecular glue degraders. Cell Chemical Biology 2021, 28, 1032-1047.S?abicki, M., Yoon, H., Koeppel, J., Nitsch, L., Roy Burman, S. S., Di Genua, C., Donovan, K. A., Sperling, A. S., Hunkeler, M., Tsai, J. M., Sharma, R., Guirguis, A., Zou, C., Chudasama, P., Gasser, J. A., Miller, P. G., Scholl, C., Frohling, S., Nowak, R. P., Fischer, E. S.,Ebert, B. L., Small-molecule-induced polymerization triggers degradation of BCL6. Nature 2020, 588, 164-168.

 

Documents 

Datasheet         COA           MSDS

 

Citations

If you know of a paper that uses this product from Tenova Pharma, please let us know.

Tenova Pharmaceuticals

CR8

$290.00

(R)-CR8 acts as a molecular glue degrader that depletes cyclin K.

Product Name CR8
Synonyms
CAS Number 294646-77-8
Related CAS
Molecular Formula C25H30N6O
Molecular Weight 430.556
SMILES CC[C@H](CO)CC1=NC(NCC2=CC=C(C=C2)C2=CC=CC=N2)=C2N=CN(C(C)C)C2=N1
Purity (HPLC) >= 95%
Physical Appearance White solid
Solubility DMSO, DMF
Shipping Conditions Room Temperature
Storage Conditions Refrigerated
Shelf Life 12 months after the date of delivery
Regulatory Statement For Research Use Only


References

S?abicki, M., Kozicka, Z., Petzold, G., Li, Y.-D., Manojkumar, M., Bunker, R. D., Donovan, K. A., Sievers, Q. L., Koeppel, J., Suchyta, D., Sperling, A. S., Fink, E. C., Gasser, J. A., Wang, L. R., Corsello, S. M., Sellar, R. S., Jan, M., Gillingham, D., Scholl, C., Frohling, S., Golub, T. R., Fischer, E. S., Thoma, N. H.,Ebert, B. L., The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K. Nature 2020, 585, 293-297.Kozicka, Z.,Thomä, N. H., Haven't got a glue: Protein surface variation for the design of molecular glue degraders. Cell Chemical Biology 2021, 28, 1032-1047.S?abicki, M., Yoon, H., Koeppel, J., Nitsch, L., Roy Burman, S. S., Di Genua, C., Donovan, K. A., Sperling, A. S., Hunkeler, M., Tsai, J. M., Sharma, R., Guirguis, A., Zou, C., Chudasama, P., Gasser, J. A., Miller, P. G., Scholl, C., Frohling, S., Nowak, R. P., Fischer, E. S.,Ebert, B. L., Small-molecule-induced polymerization triggers degradation of BCL6. Nature 2020, 588, 164-168.

 

Documents 

Datasheet         COA           MSDS

 

Citations

If you know of a paper that uses this product from Tenova Pharma, please let us know.

Size

  • 5mg
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