dCeMM2
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dCeMM2 (Compound 2) is a glue degrader. dCeMM2 induces ubiquitination and degradation of cyclin K by prompting an interaction of CDK12-cyclin K with a CRL4B ligase complex.
| Product Name | dCeMM2 |
| Synonyms | |
| CAS Number | 296771-07-8 |
| Related CAS | |
| Molecular Formula | C16H11ClN6OS |
| Molecular Weight | 370.82 |
| SMILES | ClC1=CC=C(NC(=O)CSC2=NN=C3C(NC4=CC=CC=C34)=N2)N=C1 |
| Purity (HPLC) | >= 95% |
| Physical Appearance | White solid |
| Solubility | DMSO, DMF |
| Shipping Conditions | Room Temperature |
| Storage Conditions | Refrigerated |
| Shelf Life | 12 months after the date of delivery |
| Regulatory Statement | For Research Use Only |
References
Mayor-Ruiz, C., Bauer, S., Brand, M., Kozicka, Z., Siklos, M., Imrichova, H., Kaltheuner, I. H., Hahn, E., Seiler, K., Koren, A., Petzold, G., Fellner, M., Bock, C., Müller, A. C., Zuber, J., Geyer, M., Thoma, N. H., Kubicek, S.,Winter, G. E., Rational discovery of molecular glue degraders via scalable chemical profiling. Nature Chemical Biology 2020, 16, 1199-1207.https://doi.org/10.1038/s41589-020-0594-x
Documents
Datasheet COA MSDS
Citations
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