NRX-1532
NRX-1532 - 1mg is backordered and will ship as soon as it is back in stock.
Couldn't load pickup availability
NRX-1532
NRX-1532 is an enhancer of the interaction between beta-catenin and beta-TrCP. NRX-1532 acts as molecular glue in cells to promote the ubiquitylation and subsequent degradation of mutantbeta-catenin by the 26S proteasome.
| Product Name | NRX-1532 |
| Synonyms | |
| CAS Number | n/a |
| Related CAS | |
| Molecular Formula | C16H11F3N4O2 |
| Molecular Weight | 348.285 |
| SMILES | FC(F)(F)C1=CC=C(C(=O)NC2=CC(=CC=C2)C2=CC=NN2)C(=O)N1 |
| Purity (HPLC) | >= 95% |
| Physical Appearance | White solid |
| Solubility | DMSO, DMF |
| Shipping Conditions | Room Temperature |
| Storage Conditions | Refrigerated |
| Shelf Life | 12 months after the date of delivery |
| Regulatory Statement | For Research Use Only |
References
Simonetta, K. R., Taygerly, J., Boyle, K., Basham, S. E., Padovani, C., Lou, Y., Cummins, T. J., Yung, S. L., von Soly, S. K., Kayser, F., Kuriyan, J., Rape, M., Cardozo, M., Gallop, M. A., Bence, N. F., Barsanti, P. A.,Saha, A., Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction. Nature Communications 2019, 10, 1402.
Documents
Datasheet COA MSDS
Citations
If you know of a paper that uses this product from Tenova Pharma, please let us know.
