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Tenova Pharmaceuticals  |  SKU: T55012-1mg

NRX-1933

$190.00
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NRX-1933 is an enhancer of the interaction between beta-catenin and beta-TrCP. NRX-1933 acts as molecular glue in cells to promote the ubiquitylation and subsequent degradation of mutantbeta-catenin by the 26S proteasome.

Product Name NRX-1933
Synonyms
CAS Number 2763260-30-4
Related CAS
Molecular Formula C14H9F3N6O2
Molecular Weight 350.261
SMILES FC(F)(F)C1=CC=C(C(=O)NC2=CC(=CC=C2)C2=NN=NN2)C(=O)N1
Purity (HPLC) >= 95%
Physical Appearance White solid
Solubility DMSO, DMF
Shipping Conditions Room Temperature
Storage Conditions Refrigerated
Shelf Life 12 months after the date of delivery
Regulatory Statement For Research Use Only


References

Simonetta, K. R., Taygerly, J., Boyle, K., Basham, S. E., Padovani, C., Lou, Y., Cummins, T. J., Yung, S. L., von Soly, S. K., Kayser, F., Kuriyan, J., Rape, M., Cardozo, M., Gallop, M. A., Bence, N. F., Barsanti, P. A.,Saha, A., Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction. Nature Communications 2019, 10, 1402.

 

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