SHP099
SHP099 - 5mg is backordered and will ship as soon as it is back in stock.
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SHP099 is a highly potent (IC50 = 0.071uM),selective and orally bioavailable small-molecule SHP2 inhibitor. The inhibiting SHP2 activity of SHP099 is through an allosteric mechanism. SHP099 suppresses RAS–ERK signalling to inhibit the proliferation of receptor-tyrosine-kinase-driven human cancer cells in vitro and is efficacious in mouse tumour xenograft models.
Product Name | SHP099 |
Synonyms | |
CAS Number | 1801747-42-1 |
Related CAS | |
Molecular Formula | C16H19Cl2N5 |
Molecular Weight | 352.26 |
SMILES | CC1(N)CCN(CC1)C1=CN=C(C(N)=N1)C1=C(Cl)C(Cl)=CC=C1 |
Purity (HPLC) | >= 95% |
Physical Appearance | White solid |
Solubility | DMSO, DMF |
Shipping Conditions | Room Temperature |
Storage Conditions | Refrigerated |
Shelf Life | 12 months after the date of delivery |
Regulatory Statement | For Research Use Only |
References
Ran, H., Tsutsumi, R., Araki, T.,Neel, B. G., Sticking It to Cancer with Molecular Glue for SHP2. Cancer Cell 2016, 30, 194-196. DOI: 10.1038/nature18621
Documents
Datasheet COA MSDS
Citations
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