CP-BODIPY

SNAP-tag is a self-labeling protein derived from human O6-alkylguanine-DNA-alkyltransferase. At 20 kDa, SNAP-tag is smaller than HaloTag (33 kDa), potentially reducing interference with the tagged protein’s function. SNAP-tag reacts with covalently with benzylguanine (BG)or chloropyrimidine (CP) derivatives, forming a stable thioether bonds that ensures durability for long-term experiments or harsh conditions. SNAP-tag can be used alongside other tags like CLIP-tag for multicolor labeling. Chloropyrimidine (CP) derivatives generally exhibit better cell permeability compared to their benzylguanine (BG) derivatives. CP-BODIPY is a SNAP-tag substrate containg BODIPY dye. It forms a covalent bond with the SNAP-tag protein, ensuring stable labeling for long-term tracking. BODIPY (boron-dipyrromethene, 502Ex/511Em) is widely used for its sharp absorption and emission peaks, high molar absorptivity, and excellent quantum yields. The rigid, planar structure around the boron-dipyrromethene core imparts exceptional photostability, minimal environmental sensitivity, and narrow spectral bands, making them ideal for multiplexed fluorescence applications.

References

Documents 

Datasheet          MSDS

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