Tenova Pharmaceuticals  |  SKU: T55063-100mg

5-Hydroxythalidomide

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Thalidomide-5-OH is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. It induces degradation of SALL4 (ZF2).

Product Name 5-Hydroxythalidomide
Synonyms
CAS Number 64567-60-8
Related CAS
Molecular Formula C13H10N2O5
Molecular Weight 274.232
SMILES OC1=CC2=C(C=C1)C(=O)N(C1CCC(=O)NC1=O)C2=O
Purity (HPLC) >= 95%
Physical Appearance White solid
Solubility DMSO, DMF
Shipping Conditions Room Temperature
Storage Conditions Refrigerated
Shelf Life 12 months after the date of delivery
Regulatory Statement For Research Use Only


References

Kozicka, Z., & Thoma, N. H. (2021). Haven’t got a glue: Protein surface variation for the design of molecular glue degraders. In Cell Chemical Biology (Vol. 28, Issue 7). https://doi.org/10.1016/j.chembiol.2021.04.009


Documents 

Datasheet         COA           MSDS


Citations

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