PC-6

PC-6 is a specially designed fluorescent probe for detecting SARM1 activity, built by conjugating a styryl donor group to a pyridine acceptor to form a donor–π–acceptor system. It functions through SARM1’s base-exchange reaction, where PC-6 is converted into a positively charged product (PAD6) upon incorporation into NAD, leading to strong intramolecular charge transfer and a large fluorescence shift (from ~430 nm to ~520 nm). Among a series of related probes (PC1–9), PC-6 shows the largest fluorescence increase, high sensitivity (detecting as little as 48 ng/mL enzyme), and strong selectivity for SARM1 over other NADases, making it a powerful tool for monitoring SARM1 activation in biochemical assays.

Product Name	PC-6
Synonyms
CAS Number	N/A
Related CAS	N/A
Molecular Formula	C15H15NO
Molecular Weight	225.291
Purity (HPLC)	>= 95%
Solubility	DMSO, DMF
Shipping Conditions	Shipped on gel packs
Storage Conditions	Store at -20°C and protected from light
Shelf Life	12 months after the date of delivery
Regulatory Statement	For Research Use Only

References

Li, W. H., Huang, K., Cai, Y., Wang, Q. W., Zhu, W. J., Hou, Y. N., Wang, S., Cao, S., Zhao, Z. Y., Xie, X. J., Du, Y., Lee, C. S., Lee, H. C., Zhang, H., & Zhao, Y. J. (2021). Permeant fluorescent probes visualize the activation of sarm1 and uncover an antineurodegenerative drug candidate. eLife, 10. https://doi.org/10.7554/eLife.67381

 

Documents 

Datasheet          MSDS

 

Citations

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