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Tenova Pharmaceuticals | SKU:
T55042-5mg
E7820
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£67.77
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E7820 is a molecular glue degrader like Indisulam. E7820 induce targeted degradation of the splicing factor RBM39 through recruitment of the E3 ubiquitin ligase CRL4DCAF15.
| Product Name | E7820 |
| Synonyms | |
| CAS Number | 289483-69-8 |
| Related CAS | |
| Molecular Formula | C17H12N4O2S |
| Molecular Weight | 336.37 |
| SMILES | CC1=CC=C(NS(=O)(=O)C2=CC(=CC=C2)C#N)C2=C1C(=CN2)C#N |
| Purity (HPLC) | >= 95% |
| Physical Appearance | White solid |
| Solubility | DMSO, DMF |
| Shipping Conditions | Room Temperature |
| Storage Conditions | Refrigerated |
| Shelf Life | 12 months after the date of delivery |
| Regulatory Statement | For Research Use Only |
References
Faust, T. B., Yoon, H., Nowak, R. P., Donovan, K. A., Li, Z., Cai, Q., Eleuteri, N. A., Zhang, T., Gray, N. S.,Fischer, E. S., Structural complementarity facilitates E7820-mediated degradation of RBM39 by DCAF15. Nat Chem Biol 2020, 16, 7-14.
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