CA-SS-SiR
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HaloTag is a self-labeling protein tag engineered from the haloalkane dehalogenase DhaA, originally isolated from Rhodococcus rhodochrous. Its active site binds chloroalkane (CA)substrates, forming an irreversible covalent bond. This stable linkage between the HaloTag protein and its ligand enables rapid and efficient isolation and purification of tagged proteins. CA-SS-SiR is a cleavable HaloTag ligand featuring a disulfide bond that can be cleaved using a reducing agent, such as sodium 2-mercaptoethanesulfonate (MESNA). SiR (SiR-6-COOH, 652Ex/674Em) is a far-red fluorescent dye that is bright, photostable, and cell-permeable, and it is fully compatible with standard Cy5 filter sets.
| Product Name | CA-SS-SiR |
| Synonyms | CA-SS-SiR650 |
| CAS Number | N/A |
| Related CAS | N/A |
| Molecular Formula | C42H57ClN4O6S2Si |
| Molecular Weight | 841.6 |
| Purity (HPLC) | >= 95% |
| Solubility | DMSO, DMF |
| Shipping Conditions | Room Temperature |
| Storage Conditions | Store at -20°C and protected from light |
| Shelf Life | 12 months after the date of delivery |
| Regulatory Statement | For Research Use Only |
References
Lukinavicius, G., Umezawa, K., Olivier, N. et al. A near-infrared fluorophore for live-cell super-resolution microscopy of cellular proteins. Nature Chem 5, 132–139 (2013). https://doi.org/10.1038/nchem.1546
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