CC-122
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Avadomide (CC-122) is an orally active cereblon modulator. It promotes degradation of Aiolos and Ikaros proteins.
| Product Name | CC-122 |
| Synonyms | Avadomide |
| CAS Number | 1015474-32-4 |
| Related CAS | |
| Molecular Formula | C14H14N4O3 |
| Molecular Weight | 286.291 |
| SMILES | CC1=NC2=CC=CC(N)=C2C(=O)N1C1CCC(=O)NC1=O |
| Purity (HPLC) | >= 95% |
| Physical Appearance | White solid |
| Solubility | DMSO, DMF |
| Shipping Conditions | Room Temperature |
| Storage Conditions | Refrigerated |
| Shelf Life | 12 months after the date of delivery |
| Regulatory Statement | For Research Use Only |
References
Hagner, P. R., Man, H. W., Fontanillo, C., Wang, M., Couto, S., Breider, M., Bjorklund, C., Havens, C. G., Lu, G., Rychak, E., Raymon, H., Narla, R. K., Barnes, L., Khambatta, G., Chiu, H., Kosek, J., Kang, J., Amantangelo, M. D., Waldman, M., Lopez-Girona, A., Cai, T., Pourdehnad, M., Trotter, M., Daniel, T. O., Schafer, P. H., Klippel, A., Thakurta, A., Chopra, R.,Gand Dong, G., Ding, Y., He, S.,Sheng, C., Molecular Glues for Targeted Protein Degradation: From Serendipity to Rational Discovery. Journal of Medicinal Chemistry 2021, 64, 10606-10620.
Documents
Datasheet COA MSDS
Citations
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