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Tenova Pharmaceuticals  |  SKU: T55007-5mg

compound I-7

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Compound I-7 induces degradation of Ikaros (IKZF1) through recruitment of CRBN ( EC50: 0.006 uM).

Product Name compound I-7
Synonyms
CAS Number 2631059-88-4
Related CAS
Molecular Formula C11H9ClN4O2
Molecular Weight 264.67
SMILES ClC1=CN2N=CC(N3CCC(=O)NC3=O)=C2C=C1
Purity (HPLC) >= 95%
Physical Appearance White solid
Solubility DMSO, DMF
Shipping Conditions Room Temperature
Storage Conditions Refrigerated
Shelf Life 12 months after the date of delivery
Regulatory Statement For Research Use Only


References

Axford, J., Beckwith, R. E. J., BONAZZI, S., Buschmann, N., CERNIJENKO, A., DEWHURST, J., FAZAL, A., HESSE, M. J., HOLDER, L., HORNAK, V., Imase, H., Jain, R., Jin, X., Kerrigan, J. R., Lachal, J., Ma, F., Malik, H. A., MANNING, J. R., Mckay, D., MOREAU, R. J., NIMSGERN, P., O'Brien, G., Vulpetti, A., Yamada, K.,Zhao, J. Glue degraders and methods of use thereof. WO 2021/053555, 2021.

 

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