SJ6986
SJ6986 - 5mg is backordered and will ship as soon as it is back in stock.
Couldn't load pickup availability
SJ6986
SJ6986, a novel and potent GSPT1 degrader displaying selectivity over 9000 proteins, including the classical IMiD neosubstrates such as IKZF1. SJ6986 has very good oral bioavailability (F = 84% in mice).
| Product Name | SJ6986 |
| Synonyms | |
| CAS Number | n/a |
| Related CAS | |
| Molecular Formula | C20H14F3N3O7S |
| Molecular Weight | 497.4 |
| SMILES | FC(F)(F)OC1=C(C=CC=C1)S(=O)(=O)NC1=CC2=C(C=C1)C(=O)N(C1CCC(=O)NC1=O)C2=O |
| Purity (HPLC) | >= 95% |
| Physical Appearance | White solid |
| Solubility | DMSO, DMF |
| Shipping Conditions | Room Temperature |
| Storage Conditions | Refrigerated |
| Shelf Life | 12 months after the date of delivery |
| Regulatory Statement | For Research Use Only |
References
Nishiguchi, G., Keramatnia, F., Min, J., Chang, Y., Jonchere, B., Das, S., Actis, M., Price, J., Chepyala, D., Young, B., McGowan, K., Slavish, P. J., Mayasundari, A., Jarusiewicz, J. A., Yang, L., Li, Y., Fu, X., Garrett, S. H., Papizan, J. B., Kodali, K., Peng, J., Pruett Miller, S. M., Roussel, M. F., Mullighan, C., Fischer, M.,Rankovic, Z., Identification of Potent, Selective, and Orally Bioavailable Small-Molecule GSPT1/2 Degraders from a Focused Library of Cereblon Modulators. Journal of Medicinal Chemistry 2021, 64, 7296-7311. https://doi.org/10.1021/acs.jmedchem.0c01313
Documents
Datasheet COA MSDS
Citations
If you know of a paper that uses this product from Tenova Pharma, please let us know.
