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Tenova Pharmaceuticals  |  SKU: T55006-5mg

TMX-4116

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TMX-4116 is a casein kinase 1a (CK1a) degrader. TMX-4116 shows the degradation preference for CK1a with DC50s less than 200 nM in MOLT4, Jurkat, and MM.1S cells. TMX-4116 can be used for the research of multiple myeloma.

Product Name TMX-4116
Synonyms
CAS Number 2766385-56-0
Related CAS
Molecular Formula C17H19N5O4S
Molecular Weight 389.43
SMILES COC1=C(SC=C1C1=CN(N=N1)C1CCC(=O)NC1=O)C(=O)N1CCCC1
Purity (HPLC) >= 95%
Physical Appearance White solid
Solubility DMSO, DMF
Shipping Conditions Room Temperature
Storage Conditions Refrigerated
Shelf Life 12 months after the date of delivery
Regulatory Statement For Research Use Only


References

Teng, M., Lu, W., Donovan, K. A., Sun, J., Krupnick, N. M., Nowak, R. P., Li, Y.-D., Sperling, A. S., Zhang, T., Ebert, B. L., Fischer, E. S.,Gray, N. S., Development of PDE6D and CK1a Degraders through Chemical Derivatization of FPFT-2216. Journal of Medicinal Chemistry 2022, 65, 747-756.

 

Documents 

Datasheet         COA           MSDS

 

Citations

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