Thalidomide-5-OH is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. It induces degradation of SALL4 (ZF2).
| Product Name | 5-Hydroxythalidomide |
| Synonyms | |
| CAS Number | 64567-60-8 |
| Related CAS | |
| Molecular Formula | C13H10N2O5 |
| Molecular Weight | 274.232 |
| SMILES | OC1=CC2=C(C=C1)C(=O)N(C1CCC(=O)NC1=O)C2=O |
| Purity (HPLC) | >= 95% |
| Physical Appearance | White solid |
| Solubility | DMSO, DMF |
| Shipping Conditions | Room Temperature |
| Storage Conditions | Refrigerated |
| Shelf Life | 12 months after the date of delivery |
| Regulatory Statement | For Research Use Only |
References
Kozicka, Z., & Thoma, N. H. (2021). Haven’t got a glue: Protein surface variation for the design of molecular glue degraders. In Cell Chemical Biology (Vol. 28, Issue 7). https://doi.org/10.1016/j.chembiol.2021.04.009
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