Targeted Protein Degradation

Small molecule-induced protein degradation has profound impacts on drug discovery research by providing opportunities toward traditionally undruggable targets.  Currently there are two main approaches for targeted protein degradation: proteolysis targeting chimeras (PROTACs) and molecular glues. 

PROTACs are hetero bifunctional molecules that connect a ligand of the target protein to an E3 ubiquitin ligase recruiting ligand with a linker.  PROTACs promote degradation through bring the target protein to close proximity of E3 ligase and then degraded by the ubiquitin-proteasome system.

Molecular glues are small molecules that stabilizes the interaction between two proteins that do not normally interact.  Molecular glues induce interaction between an E3 ubiquitin ligase with target proteins and cause degradation of substrates that are normally not targeted by the ligase. 

Tenova Pharma offers variety of products for targeted protein degradation research, such as molecular glues, degrader building blocks, E3 ligase ligands, linkers, E3 ligase ligand-linker conjugates, PROTACs and fluorescent probes.

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