HaloTag is a self-labeling protein derived from the haloalkane dehalogenase DhaA from Rhodococcus rhodochrous. Its active site reacts with chloroalkane substrates to form an irreversible bond. The covalent linkage between the HaloTag ligand and HaloTag protein enables rapid isolation and purification. HaloTag DBCO Ligand can be used to attach DBCO moiety to protein. DBCO has been extensively used in copper-free click chemistry.
| Product Name | HaloTag DBCO Ligand |
| Synonyms | |
| CAS Number | 1808119-16-5 |
| Related CAS | |
| Molecular Formula | C29H35ClN2O4 |
| Molecular Weight | 511.06 |
| Purity (HPLC) | >= 95% |
| Physical Appearance | Light Yellow Solid |
| Optical Properties | n/a |
| Solubility | DMSO, DMF |
| Shipping Conditions | Shipped on gel packs |
| Storage Conditions | Store at -20°C and protected from light |
| Shelf Life | 12 months after the date of delivery |
| Regulatory Statement | For Research Use Only |
References
Wilhelm, J., Kuhn, S., Tarnawski, M., Gotthard, G., Tunnermann, J., Tanzer, T., Karpenko, J., Mertes, N., Xue, L., Uhrig, U., Reinstein, J., Hiblot, J., & Johnsson, K. (2021). Kinetic and Structural Characterization of the Self-Labeling Protein Tags HaloTag7, SNAP-tag, and CLIP-tag. Biochemistry, 60(33), 2560–2575. https://doi.org/10.1021/acs.biochem.1c00262
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