HaloTag is a self-labeling protein derived from the haloalkane dehalogenase DhaA from Rhodococcus rhodochrous. Its active site reacts with chloroalkane substrates to form an irreversible bond. The covalent linkage between the HaloTag ligand and HaloTag protein enables rapid isolation and purification. HaloTag DOTA-tris(t-Bu) Ligand can be used to attach DOTA moiety to protein. DOTA has been used in many different diagnostic and therapeutic applications, such as MRI contrast agents, PET and SPECT imaging agents, and radiotherapeutic agents.
| Product Name | HaloTag DOTA-tris(t-Bu) Ligand |
| Synonyms | |
| CAS Number | 1334953-45-5 |
| Related CAS | |
| Molecular Formula | C38H72ClN5O9 |
| Molecular Weight | 778.47 |
| Purity (HPLC) | >= 95% |
| Physical Appearance | Light Yellow Solid |
| Optical Properties | n/a |
| Solubility | DMSO, DMF |
| Shipping Conditions | Shipped on gel packs |
| Storage Conditions | Store at -20°C and protected from light |
| Shelf Life | 12 months after the date of delivery |
| Regulatory Statement | For Research Use Only |
References
Wilhelm, J., Kuhn, S., Tarnawski, M., Gotthard, G., Tunnermann, J., Tanzer, T., Karpenko, J., Mertes, N., Xue, L., Uhrig, U., Reinstein, J., Hiblot, J., & Johnsson, K. (2021). Kinetic and Structural Characterization of the Self-Labeling Protein Tags HaloTag7, SNAP-tag, and CLIP-tag. Biochemistry, 60(33), 2560–2575. https://doi.org/10.1021/acs.biochem.1c00261
Documents
Citations
If you know of a paper that uses this product from Tenova Pharma, please let us know.