NBD-TM is a thiomorpholine-based fluorogenic probe for HOCl. NBD-TM proved to be the most rapid scavenger of HOCl when compared with boronate- and aminophenyl-based fluorogenic probes in a study for monitoring the chlorinating activity of Myeloperoxidase (MPO). Its high reactivity towards HOCl makes NBD-TM the probe of choice for HTS campaigns based on HOCl detection. Excitation maximum = 500 nm; emission maximum = 550 nm.
| Product Name | NDB-TM |
| Synonyms | |
| CAS Number | 871510-38-2 |
| Related CAS | |
| Molecular Formula | C10H10N4O3S |
| Molecular Weight | 266.28 |
| Purity (HPLC) | >= 95% |
| Physical Appearance | Brown Solid |
| Optical Properties | Abs/Em Maxima: 500/550nm |
| Solubility | DMSO, DMF |
| Shipping Conditions | Shipped on gel packs |
| Storage Conditions | Store at -20°C and protected from light |
| Shelf Life | 12 months after the date of delivery |
| Regulatory Statement | For Research Use Only |
References
Pierzchala, K., Pieta, M., Rola, M., Swierczynska, M., Artelska, A., Debowska, K., Podsiadly, R., Pieta, J., Zielonka, J., Sikora, A., Marcinek, A., & Michalski, R. (2022). Fluorescent probes for monitoring myeloperoxidase-derived hypochlorous acid: a comparative study. Scientific Reports, 12(1). https://doi.org/10.1038/s41598-022-13317-8
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