BI-3802 is a highly potent BCL6 degrader and inhibits the Bric-a-brac (BTB) domain of BCL6 with an IC50 of <=3 nM. BI-3802 induces the polymerization of BCL6 and promotes BCL6 degradation depended on E3 ligase SIAH1. BI-3802 has antitumor activity. Reference: Rana, S.,Natarajan, A., Small molecule induced polymerization of BCL6 facilitates SIAH1 mediated degradation. Signal Transduction and Targeted Therapy, 2021, 6, 142.
| Product Name |
BI-3802 |
| Synonyms |
|
| CAS Number |
2166387-65-9 |
| Related CAS |
|
| Molecular Formula |
C25H31ClN6O3 |
| Molecular Weight |
499.01 |
| SMILES |
CNC(=O)COC1=CC2=C(C=CC(=C2)N(C)C2=NC(=NC=C2Cl)N2C[C@@H](C)C[C@@H](C)C2)N(C)C1=O |
| Purity (HPLC) |
98% |
| Shipping Conditions |
Room Temperature |
| Storage Conditions |
Refrigerated |
| Regulatory Statemen: |
For Research Use Only |
