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BI-3802 is a highly potent BCL6 degrader and inhibits the Bric-a-brac (BTB) domain of BCL6 with an IC50 of <=3 nM. BI-3802 induces the polymerization of BCL6 and promotes BCL6 degradation depended on E3 ligase SIAH1. BI-3802 has antitumor activity. Reference: Rana, S.,Natarajan, A., Small molecule induced polymerization of BCL6 facilitates SIAH1 mediated degradation. Signal Transduction and Targeted Therapy, 2021, 6, 142.
Product Name BI-3802
CAS Number 2166387-65-9
Related CAS
Molecular Formula C25H31ClN6O3
Molecular Weight 499.01
SMILES CNC(=O)COC1=CC2=C(C=CC(=C2)N(C)C2=NC(=NC=C2Cl)N2C[C@@H](C)C[C@@H](C)C2)N(C)C1=O
Purity (HPLC) 98%
Shipping Conditions Room Temperature
Storage Conditions Refrigerated
Regulatory Statemen: For Research Use Only