Fmoc-Val-Cit-PAB-PNP - 100mg is backordered and will ship as soon as it is back in stock.
Fmoc-Val-Cit-PAB-PNP is a cleavable ADC linker used in antibody–drug conjugate (ADC) development, designed to enable enzyme-responsive payload release in tumor-targeted applications. The Val–Cit dipeptide is optimized for cathepsin B cleavage in lysosomal environments, while the para-aminobenzyl (PAB) spacer supports self-immolative release of the attached drug. The p-nitrophenyl (PNP) group functions as an efficient leaving group for conjugation to amine-containing cytotoxic payloads, facilitating reliable ADC synthesis for oncology research.
| Product Name | Fmoc-Val-Cit-PAB-PNP |
| Synonyms | Fmoc-VC-PAB-PNP |
| CAS Number | 863971-53-3 |
| Related CAS | |
| Molecular Formula | C40H42N6O10 |
| Molecular Weight | 766.808 |
| Purity (HPLC) | >= 95% |
| Solubility | DMSO, DMF |
| Shipping Conditions | Shipped on gel packs |
| Storage Conditions | Store at -20°C and protected from light |
| Shelf Life | 12 months after the date of delivery |
| Regulatory Statement | For Research Use Only |
References
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Datasheet MSDS
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