BC-Cp
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CLIP-tag is a modified version of the SNAP-tag. It is also a self-labeling protein derived from human O6-alkylguanine-DNA-alkyltransferase. Unlike the SNAP-tag, which reacts with benzylguanine (BG)or chloropyrimidine (CP) derivatives, the CLIP-tag is engineered to specifically interact with benzylcytosine (BC)derivatives. This modification allows for distinct labeling applications, enabling researchers to use both SNAP-tag and CLIP-tag in the same experiment, providing flexibility in protein labeling and tracking. BC-Cp is a CLIP-tag substrate containg methylcyclopropene moiety for click chemistry applications. The methylcyclopropene moiety can act as a dienophile in inverse electron-demand Diels-Alder (iEDDA) reactions, where it reacts with 1,2,4,5-tetrazines (Tz) to form a stable bicyclic product. This reaction is useful in bioorthogonal chemistry for bioconjugation and molecular labeling without the need for catalysts, making it highly suitable for live-cell imaging and other biological applications.
| Product Name | BC-Cp |
| Synonyms | CLIP-Cp, BC-methylcyclopropene |
| CAS Number | |
| Related CAS | |
| Molecular Formula | C18H20N4O3 |
| Molecular Weight | 340.383 |
| Purity (HPLC) | >= 95% |
| Solubility | DMSO, DMF |
| Shipping Conditions | Shipped on gel packs |
| Storage Conditions | Store at -20°C and protected from light |
| Shelf Life | 12 months after the date of delivery |
| Regulatory Statement | For Research Use Only |
References
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