BC-SiR

CLIP-tag is a modified version of the SNAP-tag. It is also a self-labeling protein derived from human O6-alkylguanine-DNA-alkyltransferase. Unlike the SNAP-tag, which reacts with benzylguanine (BG)or chloropyrimidine (CP) derivatives, the CLIP-tag is engineered to specifically interact with benzylcytosine (BC)derivatives. This modification allows for distinct labeling applications, enabling researchers to use both SNAP-tag and CLIP-tag in the same experiment, providing flexibility in protein labeling and tracking. BC-SiR is a CLIP-tag substrate containing the 6-SiR dye. It forms a covalent bond with the CLIP-tag protein, ensuring stable labeling for long-term tracking. The SiR dye (short for Silicon Rhodamine dye, 643Ex/662Em) offers several advantages, including high photostability, far-red fluorescence, and cell permeability, making it ideal for live-cell imaging and long-term studies. This enables researchers to visualize and track proteins or other cellular structures with minimal background interference.

References

Documents 

Datasheet          MSDS

Citations

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