BG-SS-Alexa Fluor 488
BG-SS-Alexa Fluor 488 - 100nmol is backordered and will ship as soon as it is back in stock.
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SNAP-tag is a self-labeling protein derived from human O6-alkylguanine-DNA-alkyltransferase. At 20 kDa, SNAP-tag is smaller than HaloTag (33 kDa), potentially reducing interference with the tagged protein’s function. SNAP-tag reacts with covalently with benzylguanine (BG)or chloropyrimidine (CP) derivatives, forming a stable thioether bonds that ensures durability for long-term experiments or harsh conditions. SNAP-tag can be used alongside other tags like CLIP-tag for multicolor labeling. BG-SS-Alexa488 is a cleavable, membrane-impermeable SNAP-tag substrate. It features a disulfide bond, allowing the non-internalized probe to be released from the cell surface using the reducing agent sodium 2-mercaptoethanesulfonate (MESNA). It allows for the rapid release of fluorescently labeled probes from the cell surface, without interfering with the population of labeled molecules retained within endosomes. Alexa Fluor 488 (494Ex/517Em) is a popular green fluorescent dye known for its brightness, stability, and versatility in various biological and biochemical applications.
| Product Name | BG-SS-Alexa Fluor 488 |
| Synonyms | SNAP-SS-Alexa Fluor 488 |
| CAS Number | |
| Related CAS | |
| Molecular Formula | C45H44N10O13S4 |
| Molecular Weight | 1061.15 |
| Purity (HPLC) | >= 95% |
| Solubility | DMSO, DMF |
| Shipping Conditions | Shipped on gel packs |
| Storage Conditions | Store at -20°C and protected from light |
| Shelf Life | 12 months after the date of delivery |
| Regulatory Statement | For Research Use Only |
References
Cole, N. B., & Donaldson, J. G. (2012). Releasable SNAP-tag probes for studying endocytosis and recycling. ACS Chemical Biology, 7(3), 464–469. https://doi.org/10.1021/cb2004252
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