HaXS8
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HaXS8 is a synthetic chemical dimerizer designed to induce covalent and irreversible intracellular dimerization between proteins tagged with HaloTag and SNAP-tag. It’s a bifunctional molecule featuring a chloroalkane group (specific for HaloTag) and an O6-benzylguanine (BG) derivative (specific for SNAP-tag), connected by a flexible polyethylene glycol (PEG) linker. When introduced to cells, HaXS8 bridges HaloTag and SNAP-tag fusion proteins by reacting covalently with their respective active sites: the chloroalkane binds irreversibly to HaloTag’s modified dehalogenase pocket, while the BG moiety forms a stable thioether bond with SNAP-tag’s engineered alkyltransferase cysteine. This dual reactivity forces the tagged proteins into close proximity, creating a stable dimer without requiring additional catalysts.
| Product Name | HaXS8 |
| Synonyms | |
| CAS Number | |
| Related CAS | |
| Molecular Formula | C35H43ClF4N6O8 |
| Molecular Weight | 787.21 |
| Purity (HPLC) | >= 95% |
| Solubility | DMSO, DMF |
| Shipping Conditions | Shipped on gel packs |
| Storage Conditions | Store at -20°C and protected from light |
| Shelf Life | 12 months after the date of delivery |
| Regulatory Statement | For Research Use Only |
References
Erhart, D., Zimmermann, M., Jacques, O., Wittwer, M. B., Ernst, B., Constable, E., Zvelebil, M., Beaufils, F., & Wymann, M. P. (2013). Chemical development of intracellular protein heterodimerizers. Chemistry and Biology, 20(4), 549–557. https://doi.org/10.1016/j.chembiol.2013.03.010
Documents
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Citations
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