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Tenova Pharmaceuticals  |  SKU: T55043-5mg

compound I-10

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Compound I-10 induces degradation of GSPT1 through recruitment of CRBN ( EC50: 0.170 uM).

Product Name compound I-10
Synonyms
CAS Number n/a
Related CAS
Molecular Formula C23H25N5O2
Molecular Weight 403.486
SMILES O=C1CCN(C2=CN=C3C=CC(=CN23)C2CCN(CC3=CC=CC=C3)CC2)C(=O)N1
Purity (HPLC) >= 95%
Physical Appearance White solid
Solubility DMSO, DMF
Shipping Conditions Room Temperature
Storage Conditions Refrigerated
Shelf Life 12 months after the date of delivery
Regulatory Statement For Research Use Only


References

Axford, J., Beckwith, R. E. J., BONAZZI, S., Buschmann, N., CERNIJENKO, A., DEWHURST, J., FAZAL, A., HESSE, M. J., HOLDER, L., HORNAK, V., Imase, H., Jain, R., Jin, X., Kerrigan, J. R., Lachal, J., Ma, F., Malik, H. A., MANNING, J. R., Mckay, D., MOREAU, R. J., NIMSGERN, P., O'Brien, G., Vulpetti, A., Yamada, K.,Zhao, J. Glue degraders and methods of use thereof. WO 2021/053555, 2021.

 

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