BC-BODIPY

CLIP-tag is a modified version of the SNAP-tag. It is also a self-labeling protein derived from human O6-alkylguanine-DNA-alkyltransferase. Unlike the SNAP-tag, which reacts with benzylguanine (BG)or chloropyrimidine (CP) derivatives, the CLIP-tag is engineered to specifically interact with benzylcytosine (BC)derivatives. This modification allows for distinct labeling applications, enabling researchers to use both SNAP-tag and CLIP-tag in the same experiment, providing flexibility in protein labeling and tracking. BC-BODIPY is a CLIP-tag substrate containg BODIPY dye and it forms a covalent bond with the CLIP-tag protein, ensuring stable labeling for long-term tracking. BODIPY (boron-dipyrromethene, 502Ex/511Em) is widely used for its sharp absorption and emission peaks, high molar absorptivity, and excellent quantum yields. The rigid, planar structure around the boron-dipyrromethene core imparts exceptional photostability, minimal environmental sensitivity, and narrow spectral bands, making them ideal for multiplexed fluorescence applications.

References

Documents 

Datasheet          MSDS

Citations

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