CA-methylcyclopropene
CA-methylcyclopropene - 100nmol is backordered and will ship as soon as it is back in stock.
Couldn't load pickup availability
HaloTag is a self-labeling protein tag engineered from the haloalkane dehalogenase DhaA, originally isolated from Rhodococcus rhodochrous. Its active site binds chloroalkane (CA)substrates, forming an irreversible covalent bond. This stable linkage between the HaloTag protein and its ligand enables rapid and efficient isolation and purification of tagged proteins. CA-Cp is a HaloTag ligand containg methylcyclopropene moiety for click chemistry applications. The methylcyclopropene moiety can act as a dienophile in inverse electron-demand Diels-Alder (iEDDA) reactions, where it reacts with 1,2,4,5-tetrazines (Tz) to form a stable bicyclic product. This reaction is useful in bioorthogonal chemistry for bioconjugation and molecular labeling without the need for catalysts, making it highly suitable for live-cell imaging and other biological applications.
| Product Name | CA-methylcyclopropene |
| Synonyms | Methylcyclopropene-Halo, Methylcyclopropene-CA |
| CAS Number | |
| Related CAS | |
| Molecular Formula | C16H28ClNO4 |
| Molecular Weight | 333.85 |
| Purity (HPLC) | >= 95% |
| Solubility | DMSO, DMF |
| Shipping Conditions | Shipped on gel packs |
| Storage Conditions | Store at -20°C and protected from light |
| Shelf Life | 12 months after the date of delivery |
| Regulatory Statement | For Research Use Only |
References
Wilhelm, J., Kuhn, S., Tarnawski, M., Gotthard, G., Tunnermann, J., Tanzer, T., Karpenko, J., Mertes, N., Xue, L., Uhrig, U., Reinstein, J., Hiblot, J., & Johnsson, K. (2021). Kinetic and Structural Characterization of the Self-Labeling Protein Tags HaloTag7, SNAP-tag, and CLIP-tag. Biochemistry, 60(33), 2560–2575. https://doi.org/10.1021/acs.biochem.1c00264
Documents
Datasheet MSDS
Citations
If you know of a paper that uses this product from Tenova Pharma, please let us know.
