CRBN5-SNAP2-0C-PIP
CRBN5-SNAP2-0C-PIP - 100nmol is backordered and will ship as soon as it is back in stock.
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CRBN5-SNAP2-0C-PIP is a SNAP PROteolysis TArgeting Chimera (SNAP-PROTAC), which recruit the VHL or CRBN-ubiquitin E3 ligases to induce the degradation of SNAP-fusion proteins. Endogenous tagging enabled the visualization and the selective depletion of a SNAP-clathrin light chain fusion protein using SNAP-PROTACs. The addition of PROTACs to the SNAP-tag reagent toolbox facilitates the comprehensive analysis of protein function with a single gene tagging event.
| Product Name | CRBN5-SNAP2-0C-PIP |
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| CAS Number | |
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| Molecular Formula | C31H30ClN7O6 |
| Molecular Weight | 632.07 |
| Purity (HPLC) | >= 95% |
| Solubility | DMSO, DMF |
| Shipping Conditions | Shipped on gel packs |
| Storage Conditions | Store at -20°C and protected from light |
| Shelf Life | 12 months after the date of delivery |
| Regulatory Statement | For Research Use Only |
References
Pol, S. A., Liljenberg, S., Barr, J., Simon, G., Wong-Dilworth, L., Paterson, D. L., Berishvili, V. P., Bottanelli, F., Kaschani, F., Kaiser, M., Pettersson, M., & Hellerschmied, D. (2024). Induced degradation of SNAP-fusion proteins. RSC Chemical Biology, 5(12), 1232–1247. https://doi.org/10.1039/D4CB00184B
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Citations
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