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Tenova Pharmaceuticals | SKU:
T55062-100mg
Trametinib
$90.00
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Trametinib - 5mg is backordered and will ship as soon as it is back in stock.
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Trametinib (GSK1120212; JTP-74057) is an orally active MEK inhibitor that inhibits MEK1 and MEK2 with IC50s of about 2 nM. Trametinib binds KRS-MEK and disrupts RAF-MEK.
| Product Name | Trametinib |
| Synonyms | |
| CAS Number | 871700-17-3 |
| Related CAS | |
| Molecular Formula | C26H23FIN5O4 |
| Molecular Weight | 615.404 |
| SMILES | CN1C(=O)C(C)=C2N(C(=O)N(C3CC3)C(=O)C2=C1NC1=C(F)C=C(I)C=C1)C1=CC(NC(C)=O)=CC=C1 |
| Purity (HPLC) | >= 95% |
| Physical Appearance | White solid |
| Solubility | DMSO, DMF |
| Shipping Conditions | Room Temperature |
| Storage Conditions | Refrigerated |
| Shelf Life | 12 months after the date of delivery |
| Regulatory Statement | For Research Use Only |
References
Khan, Z. M., Real, A. M., Marsiglia, W. M., Chow, A., Duffy, M. E., Yerabolu, J. R., Scopton, A. P.,Dar, A. C., Structural basis for the action of the drug trametinib at KSR-bound MEK. Nature 2020, 588, 509-514. https://doi.org/10.1038/s41586-020-2760-4
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Citations
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