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Trametinib (GSK1120212; JTP-74057) is an orally active MEK inhibitor that inhibits MEK1 and MEK2 with IC50s of about 2 nM. Trametinib binds KRS-MEK and disrupts RAF-MEK.

Product Name Trametinib
CAS Number 871700-17-3
Related CAS
Molecular Formula C26H23FIN5O4
Molecular Weight 615.404
SMILES CN1C(=O)C(C)=C2N(C(=O)N(C3CC3)C(=O)C2=C1NC1=C(F)C=C(I)C=C1)C1=CC(NC(C)=O)=CC=C1
Purity (HPLC) >= 95%
Physical Appearance White solid
Solubility DMSO, DMF
Shipping Conditions Room Temperature
Storage Conditions Refrigerated
Shelf Life 12 months after the date of delivery
Regulatory Statement For Research Use Only


Khan, Z. M., Real, A. M., Marsiglia, W. M., Chow, A., Duffy, M. E., Yerabolu, J. R., Scopton, A. P.,Dar, A. C., Structural basis for the action of the drug trametinib at KSR-bound MEK. Nature 2020, 588, 509-514.



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