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Trametinib (GSK1120212; JTP-74057) is an orally active MEK inhibitor that inhibits MEK1 and MEK2 with IC50s of about 2 nM. Trametinib binds KRS-MEK and disrupts RAF-MEK. Reference: Khan, Z. M., Real, A. M., Marsiglia, W. M., Chow, A., Duffy, M. E., Yerabolu, J. R., Scopton, A. P.,Dar, A. C., Structural basis for the action of the drug trametinib at KSR-bound MEK. Nature 2020, 588, 509-514.
Product Name Trametinib
CAS Number 871700-17-3
Related CAS
Molecular Formula C26H23FIN5O4
Molecular Weight 615.404
SMILES CN1C(=O)C(C)=C2N(C(=O)N(C3CC3)C(=O)C2=C1NC1=C(F)C=C(I)C=C1)C1=CC(NC(C)=O)=CC=C1
Purity (HPLC) 98%
Shipping Conditions Room Temperature
Storage Conditions Refrigerated
Regulatory Statemen: For Research Use Only