CC-90009
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Eragidomide (CC-90009) is a cereblon (CRBN) E3 ligase modulator. It acts as a molecular glue for selective degradation of GSPT1.
| Product Name | CC-90009 |
| Synonyms | Eragidomide |
| CAS Number | 1860875-51-9 |
| Related CAS | |
| Molecular Formula | C22H18ClF2N3O4 |
| Molecular Weight | 461.85 |
| SMILES | FC(F)(C(=O)NCC1=CC2=C(C=C1)C(=O)N(C2)C1CCC(=O)NC1=O)C1=CC=C(Cl)C=C1 |
| Purity (HPLC) | >= 95% |
| Physical Appearance | White solid |
| Solubility | DMSO, DMF |
| Shipping Conditions | Room Temperature |
| Storage Conditions | Refrigerated |
| Shelf Life | 12 months after the date of delivery |
| Regulatory Statement | For Research Use Only |
References
Mullard, A., Targeted protein degraders crowd into the clinic. Nat Rev Drug Discov 2021, 20, 247-250.Matyskiela, M. E., Lu, G., Ito, T., Pagarigan, B., Lu, C.-C., Miller, K., Fang, W., Wang, N.-Y., Nguyen, D., Houston, J., Carmel, G., Tran, T., Riley, M., Nosaka, L. A., Lander, G. C., Gaidarova, S., Xu, S., Ruchelman, A. L., Handa, H., Carmichael, J., Daniel, T. O., Cathers, B. E., Lopez-Girona, A.,Chamberlain, P. P., A novel cereblon modulator recruits GSPT1 to the CRL4CRBN ubiquitin ligase. Nature 2016, 535, 252-257.
Documents
Datasheet COA MSDS
Citations
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