Eragidomide (CC-90009) is a cereblon (CRBN) E3 ligase modulator. It acts as a molecular glue for selective degradation of GSPT1. Reference: Mullard, A., Targeted protein degraders crowd into the clinic. Nat Rev Drug Discov 2021, 20, 247-250.Matyskiela, M. E., Lu, G., Ito, T., Pagarigan, B., Lu, C.-C., Miller, K., Fang, W., Wang, N.-Y., Nguyen, D., Houston, J., Carmel, G., Tran, T., Riley, M., Nosaka, L. A., Lander, G. C., Gaidarova, S., Xu, S., Ruchelman, A. L., Handa, H., Carmichael, J., Daniel, T. O., Cathers, B. E., Lopez-Girona, A.,Chamberlain, P. P., A novel cereblon modulator recruits GSPT1 to the CRL4CRBN ubiquitin ligase. Nature 2016, 535, 252-257.
Product Name |
CC-90009 |
Synonyms |
Eragidomide |
CAS Number |
1860875-51-9 |
Related CAS |
|
Molecular Formula |
C22H18ClF2N3O4 |
Molecular Weight |
461.85 |
SMILES |
FC(F)(C(=O)NCC1=CC2=C(C=C1)C(=O)N(C2)C1CCC(=O)NC1=O)C1=CC=C(Cl)C=C1 |
Purity (HPLC) |
98% |
Shipping Conditions |
Room Temperature |
Storage Conditions |
Refrigerated |
Regulatory Statemen: |
For Research Use Only |