NCT 02
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NCT02 is a molecular glue cyclin K degrader. NCT02 induces ubiquitination of cyclin K (CCNK) and proteasomal degradation of CCNK and its complex partner CDK12.
Product Name | NCT 02 |
Synonyms | |
CAS Number | 790245-61-3 |
Related CAS | |
Molecular Formula | C17H16N2O2S |
Molecular Weight | 312.39 |
SMILES | CC1=CN=C(NC(=O)CC2=COC3=CC4=C(CCC4)C=C23)S1 |
Purity (HPLC) | >= 95% |
Physical Appearance | White solid |
Solubility | DMSO, DMF |
Shipping Conditions | Room Temperature |
Storage Conditions | Refrigerated |
Shelf Life | 12 months after the date of delivery |
Regulatory Statement | For Research Use Only |
References
Dieter, S. M., Siegl, C., Codo, P. L., Huerta, M., Ostermann-Parucha, A. L., Schulz, E., Zowada, M. K., Martin, S., Laaber, K., Nowrouzi, A., Blatter, M., Kreth, S., Westermann, F., Benner, A., Uhrig, U., Putzker, K., Lewis, J., Haegebarth, A., Mumberg, D., Holton, S. J., Weiske, J., Toepper, L.-M., Scheib, U., Siemeister, G., Ball, C. R., Kuster, B., Stoehr, G., Hahne, H., Johannes, S., Lange, M., Herbst, F.,Glimm, H., Degradation of CCNK/CDK12 is a druggable vulnerability of colorectal cancer. Cell Reports 2021, 36.
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Citations
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