NCT02 is a molecular glue cyclin K degrader. NCT02 induces ubiquitination of cyclin K (CCNK) and proteasomal degradation of CCNK and its complex partner CDK12. Reference: Dieter, S. M., Siegl, C., Codo, P. L., Huerta, M., Ostermann-Parucha, A. L., Schulz, E., Zowada, M. K., Martin, S., Laaber, K., Nowrouzi, A., Blatter, M., Kreth, S., Westermann, F., Benner, A., Uhrig, U., Putzker, K., Lewis, J., Haegebarth, A., Mumberg, D., Holton, S. J., Weiske, J., Toepper, L.-M., Scheib, U., Siemeister, G., Ball, C. R., Kuster, B., Stoehr, G., Hahne, H., Johannes, S., Lange, M., Herbst, F.,Glimm, H., Degradation of CCNK/CDK12 is a druggable vulnerability of colorectal cancer. Cell Reports 2021, 36.
| Product Name |
NCT 02 |
| Synonyms |
|
| CAS Number |
790245-61-3 |
| Related CAS |
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| Molecular Formula |
C17H16N2O2S |
| Molecular Weight |
312.39 |
| SMILES |
CC1=CN=C(NC(=O)CC2=COC3=CC4=C(CCC4)C=C23)S1 |
| Purity (HPLC) |
98% |
| Shipping Conditions |
Room Temperature |
| Storage Conditions |
Refrigerated |
| Regulatory Statemen: |
For Research Use Only |
