Indisulam promotes the recruitment of RBM39 (RNA binding motif protein 39) to the CUL4-DCAF15 E3 ubiquitin ligase, leading to RBM39 polyubiquitination and proteasomal degradation.
Product Name | Indisulam |
Synonyms | |
CAS Number | 165668-41-7 |
Related CAS | |
Molecular Formula | C14H12ClN3O4S2 |
Molecular Weight | 385.84 |
SMILES | NS(=O)(=O)C1=CC=C(C=C1)S(=O)(=O)NC1=CC=CC2=C1NC=C2Cl |
Purity (HPLC) | >= 95% |
Physical Appearance | White solid |
Solubility | DMSO, DMF |
Shipping Conditions | Room Temperature |
Storage Conditions | Refrigerated |
Shelf Life | 12 months after the date of delivery |
Regulatory Statement | For Research Use Only |
References
Rana, S., Mallareddy, J. R., Singh, S., Boghean, L.,Natarajan, A., Inhibitors, PROTACs and Molecular Glues as Diverse Therapeutic Modalities to Target Cyclin-Dependent Kinase. Cancers 2021, 13, 5506.
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