Indisulam promotes the recruitment of RBM39 (RNA binding motif protein 39) to the CUL4-DCAF15 E3 ubiquitin ligase, leading to RBM39 polyubiquitination and proteasomal degradation. Reference: Rana, S., Mallareddy, J. R., Singh, S., Boghean, L.,Natarajan, A., Inhibitors, PROTACs and Molecular Glues as Diverse Therapeutic Modalities to Target Cyclin-Dependent Kinase. Cancers 2021, 13, 5506.
| Product Name |
Indisulam |
| Synonyms |
|
| CAS Number |
165668-41-7 |
| Related CAS |
|
| Molecular Formula |
C14H12ClN3O4S2 |
| Molecular Weight |
385.84 |
| SMILES |
NS(=O)(=O)C1=CC=C(C=C1)S(=O)(=O)NC1=CC=CC2=C1NC=C2Cl |
| Purity (HPLC) |
98% |
| Shipping Conditions |
Room Temperature |
| Storage Conditions |
Refrigerated |
| Regulatory Statemen: |
For Research Use Only |
