SHP099 is a highly potent (IC50 = 0.071uM),selective and orally bioavailable small-molecule SHP2 inhibitor. The inhibiting SHP2 activity of SHP099 is through an allosteric mechanism. SHP099 suppresses RAS–ERK signalling to inhibit the proliferation of receptor-tyrosine-kinase-driven human cancer cells in vitro and is efficacious in mouse tumour xenograft models.
| Product Name | SHP099 |
| Synonyms | |
| CAS Number | 1801747-42-1 |
| Related CAS | |
| Molecular Formula | C16H19Cl2N5 |
| Molecular Weight | 352.26 |
| SMILES | CC1(N)CCN(CC1)C1=CN=C(C(N)=N1)C1=C(Cl)C(Cl)=CC=C1 |
| Purity (HPLC) | >= 95% |
| Physical Appearance | White solid |
| Solubility | DMSO, DMF |
| Shipping Conditions | Room Temperature |
| Storage Conditions | Refrigerated |
| Shelf Life | 12 months after the date of delivery |
| Regulatory Statement | For Research Use Only |
References
Ran, H., Tsutsumi, R., Araki, T.,Neel, B. G., Sticking It to Cancer with Molecular Glue for SHP2. Cancer Cell 2016, 30, 194-196. DOI: 10.1038/nature18621
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